Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.40 |
| ▸ | PPARA | Q07869 | 10/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17911630 | 0.89 | ESR1 (0.39) | PPARGPPARAPOLBCYP1A2CYP2D6 | |
| SCHEMBL11241942 | 0.84 | PPARA (0.41) | PPARGPPARAPOLBSLC6A4L3MBTL1 | |
| SCHEMBL27809243 | 0.80 | L3MBTL1 (0.40) | PPARGPPARAPOLBSLC6A4L3MBTL1 | |
| SCHEMBL4258653 | 0.79 | ALDH1A1 (0.40) | PPARGPPARASLC6A4L3MBTL1CYP1A2 | |
| SCHEMBL2106186 | 0.79 | ALDH1A1 (0.40) | PPARGPPARASLC6A4L3MBTL1CYP1A2 | |
| SCHEMBL19088418 | 0.78 | L3MBTL1 (0.44) | PPARGPPARAPOLBSLC6A4L3MBTL1 | |
| SCHEMBL1109844 | 0.78 | SLC6A4 (0.39) | PPARGPPARASLC6A4TSHRNPSR1 | |
| SCHEMBL11096221 | 0.78 | PPARA (0.46) | PPARGPPARASLC6A4GAA | |
| SCHEMBL13123958 | 0.77 | PPARA (0.41) | PPARGPPARAPOLBSLC6A4L3MBTL1 | |
| SCHEMBL9191274 | 0.77 | SIGMAR1 (0.49) | PPARGPPARAPOLBL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053233-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999040080-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 1999-08-12 | — | — | WO | disclosed |
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |
| EP-0049060-A1 | Imidazoles | BEECHAM GROUP PLC (GB) | 1982-04-07 | — | — | EP | disclosed |