Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415425 | 0.90 | ELANE (0.44) | ACVR1NPC1RAB9ATGFBR1BMPR1B | |
| SCHEMBL9365338 | 0.87 | PARP1 (0.43) | ACVR1NPC1RAB9ATGFBR1BMPR1B | |
| SCHEMBL9360266 | 0.81 | ACVR1 (0.43) | ACVR1IDO1MAPTELANECYP1A2 | |
| SCHEMBL7276535 | 0.74 | LMNA (0.43) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL9360294 | 0.70 | NPC1 (0.49) | NPC1RAB9ATGFBR1KDM4EALDH1A1 | |
| SCHEMBL9360263 | 0.69 | NPC1 (0.47) | ACVR1NPC1RAB9ATGFBR1BMPR1B | |
| SCHEMBL805503 | 0.69 | LOXL2 (0.64) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL9360720 | 0.68 | PARP1 (0.39) | ALDH1A1AURKB | |
| SCHEMBL29699887 | 0.68 | CYP1A2 (0.60) | NPC1RAB9ATGFBR1KDM4EALDH1A1 | |
| SCHEMBL1227713 | 0.68 | CYP1A2 (0.60) | NPC1RAB9ATGFBR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610171-A | Inhibition of metastasis in patients having cancer with pyridyloxazole-2-ones | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0428105-B1 | Use of quinolyl- and isoquinolyloxazole-2-ones for the production of a medicament for the prevention of glycoprotein enveloped virus infectivity | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0428107-B1 | Use of quinolyl-and isoquinolyloxanole-2-ones for the production of a medicament for the treatment of multi-drug resistant tumors | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0539575-A1 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES. | MERRELL DOW PHARMA (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992020337-A2 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-11-26 | — | — | WO | disclosed |