Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414005 | 1.00 | SIGMAR1 (0.46) | SIGMAR1CHRM5CHRM1CHRM3FABP7 | |
| SCHEMBL7414031 | 0.79 | SIGMAR1 (0.42) | SIGMAR1CHRM5CHRM1CHRM3FABP7 | |
| SCHEMBL9465607 | 0.79 | SIGMAR1 (0.42) | SIGMAR1CHRM5CHRM1CHRM3FABP7 | |
| SCHEMBL7412853 | 0.74 | SIGMAR1 (0.49) | SIGMAR1CHRM5CHRM1CHRM3DRD3 | |
| SCHEMBL7412849 | 0.74 | SIGMAR1 (0.49) | SIGMAR1CHRM5CHRM1CHRM3DRD3 | |
| SCHEMBL19390631 | 0.72 | SIGMAR1 (0.60) | SIGMAR1CHRM5CHRM1CHRM3 | |
| SCHEMBL16359488 | 0.72 | SIGMAR1 (0.60) | SIGMAR1CHRM5CHRM1CHRM3 | |
| SCHEMBL16359786 | 0.72 | SIGMAR1 (0.60) | SIGMAR1CHRM5CHRM1CHRM3 | |
| SCHEMBL6753602 | 0.71 | KDM1A (0.49) | MAOADRD2OPRM1DRD3TP53 | |
| SCHEMBL6753603 | 0.71 | KDM1A (0.49) | MAOADRD2OPRM1DRD3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276026-A | Tetrahydroethanonaphthaleneamine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-5202486-A | Tetrahydroethanonaphthaleneamine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |