Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555012 | 0.86 | CHRNB2 (0.33) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8551114 | 0.86 | CHRNB2 (0.33) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8671400 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL7409243 | 0.82 | CHRNB2 (0.30) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8555994 | 0.81 | CHRNB2 (0.33) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8554469 | 0.81 | IRAK4 (0.40) | — | |
| SCHEMBL7816781 | 0.80 | SLC6A2 (0.32) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8552096 | 0.77 | SLC6A2 (0.33) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8554842 | 0.77 | KDM4E (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL7410997 | 0.76 | SLC6A3 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | claimed |