Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409269 | 0.85 | P2RX3 (0.40) | P2RX3KDM4EALDH1A1HPGDCYP3A4 | |
| SCHEMBL7414967 | 0.78 | DYRK1A (0.47) | P2RX3KDM4EALDH1A1MAPTCTNNB1 | |
| SCHEMBL7407811 | 0.77 | P2RX3 (0.42) | P2RX3ALDH1A1 | |
| SCHEMBL7409652 | 0.76 | DYRK1A (0.54) | P2RX3KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL10741271 | 0.74 | DYRK1A (0.40) | P2RX3ALDH1A1MAPTTP53DYRK1A | |
| SCHEMBL10739220 | 0.73 | DYRK1A (0.39) | P2RX3MAPTTP53DYRK1AHTR2B | |
| SCHEMBL10741229 | 0.72 | P2RX3 (0.41) | P2RX3DYRK1A | |
| SCHEMBL7412014 | 0.72 | TNF (0.43) | P2RX3KDM4ETP53DYRK1A | |
| SCHEMBL10957458 | 0.70 | TSHR (0.47) | KDM4EALDH1A1HPGDMAPTTP53 | |
| SCHEMBL7412075 | 0.70 | DYRK1A (0.47) | P2RX3CTNNB1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |