Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.54 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414967 | 0.91 | DYRK1A (0.47) | DYRK1AP2RX3MTNR1AMTNR1BMAPT | |
| SCHEMBL7412859 | 0.84 | DYRK1A (0.64) | DYRK1AP2RX3KMOMAPTKDM4E | |
| SCHEMBL7408633 | 0.77 | DYRK1A (0.55) | DYRK1AP2RX3MAPTKDM4EALDH1A1 | |
| SCHEMBL7414015 | 0.76 | P2RX3 (0.37) | DYRK1AP2RX3MAPTKDM4EALDH1A1 | |
| SCHEMBL7414631 | 0.76 | DYRK1A (0.54) | DYRK1AP2RX3KMOMTNR1AMTNR1B | |
| SCHEMBL14347328 | 0.74 | CTNNB1 (0.52) | P2RX3KDM4EALDH1A1GAA | |
| SCHEMBL7418131 | 0.74 | KMO (0.41) | P2RX3KMOMAPTKDM4EALDH1A1 | |
| SCHEMBL7405772 | 0.74 | DYRK1A (0.51) | DYRK1AP2RX3KMOMTNR1AMTNR1B | |
| SCHEMBL29071996 | 0.72 | PIK3R1 (0.46) | P2RX3MAPT | |
| SCHEMBL23150349 | 0.70 | DYRK1A (1.00) | DYRK1AHASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |