Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | RORA | P35398 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409652 | 0.91 | DYRK1A (0.54) | DYRK1AMAPTP2RX3ALDH1A1KDM4E | |
| SCHEMBL7408633 | 0.84 | DYRK1A (0.55) | DYRK1AMAPTP2RX3HSD17B10MEN1 | |
| SCHEMBL7414015 | 0.78 | P2RX3 (0.37) | DYRK1AMAPTP2RX3ALDH1A1KDM4E | |
| SCHEMBL7412859 | 0.77 | DYRK1A (0.64) | DYRK1AMAPTP2RX3ALDH1A1KDM4E | |
| SCHEMBL7405772 | 0.76 | DYRK1A (0.51) | DYRK1AMAPTP2RX3HSD17B10ALDH1A1 | |
| SCHEMBL14347328 | 0.74 | CTNNB1 (0.52) | P2RX3MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7407798 | 0.74 | WEE1 (0.47) | MAPTP2RX3RORARORCRORB | |
| SCHEMBL7414631 | 0.74 | DYRK1A (0.54) | DYRK1AP2RX3MTNR1AMTNR1B | |
| SCHEMBL10745759 | 0.73 | CASP3 (0.58) | DYRK1AMAPTP2RX3HSD17B10ALDH1A1 | |
| SCHEMBL13178171 | 0.72 | CCR2 (0.49) | MAPTP2RX3MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |