SCHEMBL7414173

SCHEMBL7414173

Cc1ccc(S(=O)(=O)OC2CCc3c(c4ccccc4n3CCN(C)C)C2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 13/20 0.50
TBXA2R P21731 6/20 0.47
PTGDR Q13258 6/20 0.47
PTGDR2 Q9Y5Y4 6/20 0.47
CHRM2 P08172 1/20 0.43
HTR1A P08908 1/20 0.43
CHRM5 P08912 1/20 0.43
ADRA2A P08913 1/20 0.43
DRD2 P14416 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
CHRM3 P20309 1/20 0.43
DRD4 P21917 1/20 0.43
SLC6A2 P23975 1/20 0.43
HRH2 P25021 1/20 0.43
HTR2A P28223 1/20 0.43
HTR2C P28335 1/20 0.43
AVPR2 P30518 1/20 0.43
ADRA1A P35348 1/20 0.43
HRH1 P35367 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7408736 0.94 HTR6 (0.52) HTR6TBXA2RPTGDRPTGDR2CHRM2
SCHEMBL7406680 0.85 HTR6 (0.46) HTR6TBXA2RPTGDRPTGDR2CHRM2
SCHEMBL7407904 0.85 HTR6 (0.51) HTR6HTR2AHTR2CCYP2D6
SCHEMBL7414266 0.83 PTGS1 (0.46) HTR6TBXA2RPTGDRPTGDR2
SCHEMBL7408765 0.77 HTR6 (0.46) HTR6CYP2D6
SCHEMBL7413011 0.77 PTGDR2 (0.46) HTR6TBXA2RPTGDRPTGDR2CHRM2
Hydrochloric Acid SCHEMBL7452433 0.76 PTGDR2 (0.45) HTR6TBXA2RPTGDRPTGDR2CHRM2
SCHEMBL7412035 0.76 HTR6 (0.55) HTR6TBXA2RPTGDRPTGDR2CHRM2
SCHEMBL7410175 0.74 DRD2 (0.58) HTR6TBXA2RPTGDRPTGDR2CHRM2
SCHEMBL7405699 0.72 HTR6 (0.38) HTR6TBXA2RPTGDRPTGDR2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4257952-A PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES STERLING DRUG INC. (US) 1981-03-24 US disclosed
US-4172834-A ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS STERLING DRUG INC. (US) 1979-10-30 US disclosed
US-4062864-A ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1977-12-13 US disclosed
US-3959309-A ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1976-05-25 US disclosed