Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.59 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.51 |
| ▸ | TFEB | P19484 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478629 | 1.00 | LMNA (0.59) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL8040501 | 0.91 | LMNA (0.64) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL998236 | 0.91 | LMNA (0.64) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL7415408 | 0.86 | NFE2L2 (0.55) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL10353470 | 0.85 | MAPT (0.61) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL11002399 | 0.85 | MAPT (0.61) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL10971775 | 0.83 | KMT2A (0.46) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL3626826 | 0.83 | LMNA (0.62) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL2066256 | 0.83 | LMNA (0.62) | LMNAKMT2AKDM4EMAPTPKM | |
| SCHEMBL11763787 | 0.81 | KDM4E (0.59) | LMNAKMT2AKDM4EMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0126094-B1 | NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS | CERMOL S.A. (CH) | 1990-06-20 | — | — | EP | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |
| EP-0126094-A1 | NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS. | CERMOL SA (CH) | 1984-11-28 | — | — | EP | disclosed |
| WO-1984002132-A1 | NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS | CERMOL SA (CH) | 1984-06-07 | — | — | WO | disclosed |