Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270821 | 0.73 | LMNA (0.43) | MAPTMAOAMAOBEPHX2EGFR | |
| SCHEMBL30874982 | 0.72 | MAPT (0.65) | MAPTMEN1NPC1GAARAB9A | |
| SCHEMBL3360447 | 0.72 | CYP2A6 (0.41) | TP53MAPTMEN1NPC1GAA | |
| SCHEMBL29124061 | 0.70 | CDK5 (0.47) | TP53MAPTPOLBHPGD | |
| SCHEMBL87109 | 0.70 | DNMT1 (0.42) | TP53MAPTMEN1RAB9AKMT2A | |
| SCHEMBL3606772 | 0.70 | MAOA (0.42) | MAPTMEN1NPC1GAAKMT2A | |
| SCHEMBL6796193 | 0.69 | MAOB (0.45) | MAPTMEN1GAAKMT2ATDP1 | |
| SCHEMBL16254014 | 0.69 | HSD17B10 (0.46) | TP53MAPTTDP1POLB | |
| SCHEMBL8944351 | 0.69 | CYP2C19 (0.47) | TP53MAPTNPC1POLBHPGD | |
| SCHEMBL10510390 | 0.69 | HPGD (0.47) | TP53MAPTGAAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234561-A2 | 2,3-Dihydro-2-phenyl-5-aminoalkyl-naphtho [1,2-b]-1,4-thiazepin-4(5H)-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-02 | — | — | EP | disclosed |
| US-4652561-A | HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |