SCHEMBL7414510

SCHEMBL7414510

COc1cc([N+](=O)[O-])c(CCCC(=O)O)cc1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 1/20 0.49
RAB9A P51151 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 2/20 0.43
CYP1A2 P05177 2/20 0.43
SNCA P37840 1/20 0.42
ALDH1A1 P00352 4/20 0.42
TDP1 Q9NUW8 2/20 0.42
POLB P06746 1/20 0.42
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 2/20 0.41
TPMT P51580 1/20 0.41
ALOX15 P16050 1/20 0.40
ALOX12 P18054 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
IMPDH2 P12268 1/20 0.40
KDM4E B2RXH2 2/20 0.40
HTT P42858 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7410818 0.95 CTSD (0.45) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL7407867 0.91 CTSD (0.57) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL9249682 0.86 CTSD (0.53) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL7415175 0.85 CTSD (0.53) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL9191298 0.83 RAB9A (0.53) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL9250162 0.82 RAB9A (0.54) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL8848662 0.80 SNCA (0.57) CYP1A2SNCAALDH1A1TDP1ALOX15
SCHEMBL13324857 0.79 SNCA (0.50) RAB9ASMN1; SMN2NPC1SNCAALDH1A1
SCHEMBL6858339 0.78 CTSD (0.46) CTSDRAB9ASMN1; SMN2NPC1CYP1A2
SCHEMBL3836319 0.77 F13A1 (0.53) SMN1; SMN2CYP1A2ALDH1A1TDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150412-A SUCH AS 4-(5-HYDROXY-4-METHOXY-2-NITROPHENYL)BUTANOIC ACID; ADMINISTERING TO INHIBIT CATECHOL-O-METHYL TRANSFERASE; TREATING PARKINSON'S DISEASE OR HYPERTENSION ORION-YHTYMA OY (FI) 2000-11-21 US disclosed
WO-1996037456-A1 NEW CATECHOL DERIVATIVES Orion-Yhtymä Oy (FI) 1996-11-28 WO disclosed