Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL30357950 | 0.95 | MAPT (0.48) | SHMT2MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7409297 | 0.84 | POLB (0.66) | MAPTALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL8894242 | 0.83 | SHMT2 (0.50) | SHMT2MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL8894236 | 0.83 | SHMT2 (0.50) | SHMT2MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL7414908 | 0.82 | MAPT (0.49) | SHMT2MAPTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL10661968 | 0.80 | TSHR (0.46) | SHMT2ALDH1A1LMNAL3MBTL1POLB | |
| SCHEMBL10662501 | 0.80 | SHMT2 (0.45) | SHMT2MAPTLMNAL3MBTL1POLB | |
| SCHEMBL10669664 | 0.78 | MAPT (0.54) | MAPTL3MBTL1POLBTP53DRD4 | |
| Fumaric Acid SCHEMBL10780013 | 0.77 | ALDH1A1 (0.44) | SHMT2MAPTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL29388229 | 0.76 | MEN1 (0.42) | MAPTALDH1A1L3MBTL1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643915-A | ANTIINFLAMMATORY AGENTS | ANDRULIS PHARMACEUTICALS CORP. (US) | 1997-07-01 | — | — | US | claimed |
| US-4584292-A | Antihypertensive 1,5-benzothiazepine derivatives and compositions thereof | KOTOBUKI SEIYAKU CO., LTD. (JP) | 1986-04-22 | — | — | US | claimed |
| US-5643915-A | ANTIINFLAMMATORY AGENTS | ANDRULIS PHARMACEUTICALS CORP. (US) | 1997-07-01 | — | — | US | disclosed |