Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7200209 | 0.87 | PKM (0.51) | ALDH1A1SLC1A3SLC1A2SLC1A1ITGAV | |
| SCHEMBL8415212 | 0.86 | PKM (0.48) | ALDH1A1SLC1A3SLC1A2SLC1A1ITGAV | |
| SCHEMBL5320463 | 0.85 | ITGAV (0.51) | ALDH1A1GAASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL2842146 | 0.83 | MEP1B (0.68) | MMP1MMP12PKMMEP1B | |
| SCHEMBL15548708 | 0.83 | ALDH1A1 (0.53) | ALDH1A1GAASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL28216424 | 0.81 | CA1 (0.56) | MMP1SLC1A3SLC1A2SLC1A1ITGAV | |
| SCHEMBL27463180 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MAPTPKMMEP1BKMT2A | |
| SCHEMBL4183041 | 0.79 | MAPT (0.68) | ALDH1A1MMP1GAAMMP12PKLR | |
| SCHEMBL11128334 | 0.79 | ALDH1A1 (0.67) | ALDH1A1PKLRCA12CA9 | |
| SCHEMBL30194714 | 0.78 | PKM (0.53) | ALDH1A1SLC1A3SLC1A2SLC1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287456-B1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYL OR HETEROARYL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN) | 2020-08-26 | — | — | EP | claimed |
| CN-113507943-B | Magnetic resonance imaging medicament containing deuterated sarcosine and diagnostic method using same | 索尔维克斯有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-113507943-A | Magnetic resonance imaging drug containing deuterated sarcosine and diagnostic method using same | 索尔维克斯有限公司 | 2021-10-15 | — | — | CN | disclosed |
| CN-108025574-B | Thermal recording medium | 三光株式会社 | 2019-04-16 | — | — | CN | disclosed |
| CN-108025574-A | Thermal recording medium | 三光株式会社 | 2018-05-11 | — | — | CN | disclosed |
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-20130165446-A1 | BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE | HORIKOSHI, HIROYOSHI (CA) | 2013-06-27 | — | — | US | disclosed |
| EP-2581373-A1 | BENZO- OR PYRIDO-IMIDAZOLE DERIVATIVE | Fujita, Takashi (JP) | 2013-04-17 | — | — | EP | disclosed |
| CN-101443349-A | Compounds and compositions as channel activating protease inhibitors | IRM LLC (VG) | 2009-05-27 | — | — | CN | disclosed |
| EP-1027333-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2000-11-08 | — | — | EP | disclosed |
| US-6133297-A | 4-((SUBSTITUTED)AMINO(SUBSTITUTED)ALKYLCARBONYLAMINO (SUBTITUTED)ALKYLAMINO)PYRIDINE COMPOUNDS OF GIVEN FORMULA; ADMINISTERING TO TREAT THROMBOSIS | MERCK & CO., INC. (US) | 2000-10-17 | — | — | US | disclosed |
| EP-1027333-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999016750-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165446-A1 | BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE | PPARG, PPARA, PPARD | ALDH1A1 1612/4885MMP1 3426/4885GAA 2338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.