Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL7412898 | 0.77 | TDP1 (0.49) | TDP1ALDH1A1KMT2AMEN1L3MBTL1 | |
| Ethylene SCHEMBL7409706 | 0.77 | ALDH1A1 (0.34) | ALDH1A1L3MBTL1LMNACYP3A4MAPK1 | |
| SCHEMBL31514659 | 0.71 | GPR35 (0.42) | ALDH1A1HPGDL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL31514650 | 0.71 | GPR35 (0.42) | ALDH1A1HPGDL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL4864448 | 0.69 | TDP1 (0.57) | TDP1VCAM1ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL38652666 | 0.69 | TDP1 (0.52) | TDP1VCAM1ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL7415021 | 0.69 | ALDH1A1 (0.37) | TDP1VCAM1ALDH1A1HPGDGAA | |
| SCHEMBL11091159 | 0.68 | TDP1 (0.56) | TDP1VCAM1ALDH1A1KMT2AMEN1 | |
| SCHEMBL27490702 | 0.68 | ALDH1A1 (0.50) | VCAM1ALDH1A1HPGDGAAKMT2A | |
| SCHEMBL2910425 | 0.68 | TDP1 (0.67) | TDP1VCAM1ALDH1A1SMN1; SMN2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |