Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL7415017 | 0.77 | TDP1 (0.39) | ALDH1A1LMNACYP3A4MAPK1L3MBTL1 | |
| Ethylene SCHEMBL7414602 | 0.76 | CD44 (0.39) | ALDH1A1CYP3A4KDM4EL3MBTL1 | |
| SCHEMBL23088053 | 0.72 | ALDH1A1 (0.43) | ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL11347334 | 0.67 | SKP2 (0.40) | ALDH1A1LMNACYP3A4KDM4E | |
| SCHEMBL12709973 | 0.66 | TSHR (0.41) | ALDH1A1POLBKDM4E | |
| SCHEMBL4830174 | 0.65 | TDP1 (0.36) | ALDH1A1CYP3A4KDM4EL3MBTL1 | |
| 1,2-Dichlorobenzene SCHEMBL28814715 | 0.64 | LMNA (0.46) | ALDH1A1LMNAPOLBCYP3A4 | |
| SCHEMBL7018050 | 0.64 | DPP4 (0.45) | ALDH1A1LMNAPOLBCYP3A4KDM4E | |
| SCHEMBL21865745 | 0.64 | TDP1 (0.34) | ALDH1A1POLBCYP3A4L3MBTL1 | |
| SCHEMBL8932344 | 0.64 | CCNC (0.35) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |