Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PRSS8 | Q16651 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042854 | 0.84 | PRSS8 (0.49) | ELANEPRSS8CTSSCYP3A4CYP2C9 | |
| SCHEMBL7049761 | 0.79 | ELANE (0.46) | ELANEPRSS8 | |
| SCHEMBL6465159 | 0.78 | FAAH (0.44) | CTSSCYP3A4CYP2C9 | |
| SCHEMBL7044878 | 0.77 | ELANE (0.41) | ELANEPRSS8CTSSCYP3A4CYP2C9 | |
| SCHEMBL7046968 | 0.77 | ELANE (0.44) | ELANEATMPRSS8 | |
| SCHEMBL7045499 | 0.77 | ELANE (0.43) | ELANEATMPRSS8 | |
| SCHEMBL6062828 | 0.75 | PRSS8 (0.43) | ELANEATMPRSS8CTSSCASP3 | |
| SCHEMBL7046461 | 0.74 | ELANE (0.43) | ELANEATMPRSS8 | |
| SCHEMBL7042850 | 0.73 | PRSS8 (0.46) | ELANEATMPRSS8CTSSCYP3A4 | |
| SCHEMBL7415173 | 0.71 | PRSS8 (0.41) | ELANEATMPRSS8CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |