Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS8 | Q16651 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045289 | 0.88 | PRSS8 (0.45) | PRSS8FAAHCES1DAGLAHDAC1 | |
| SCHEMBL7042166 | 0.78 | DAGLA (0.44) | PRSS8FAAHCES1DAGLACTSL | |
| SCHEMBL6062562 | 0.78 | DAGLA (0.44) | PRSS8FAAHCES1DAGLACTSL | |
| SCHEMBL6062828 | 0.76 | PRSS8 (0.43) | PRSS8FAAHCES1DAGLAHDAC1 | |
| SCHEMBL7042850 | 0.74 | PRSS8 (0.46) | PRSS8ELANECA1ATMCA5A | |
| SCHEMBL7044871 | 0.73 | FAAH (0.40) | PRSS8FAAHCES1DAGLAELANE | |
| SCHEMBL7042854 | 0.71 | PRSS8 (0.49) | PRSS8ELANECTSLCTSBCTSS | |
| SCHEMBL7415176 | 0.71 | ELANE (0.44) | PRSS8ELANEATMCTSS | |
| SCHEMBL6632064 | 0.66 | FAAH (0.37) | FAAHCES1DAGLACTSSXDH | |
| SCHEMBL6466347 | 0.65 | CTSK (0.58) | CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |