Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | CCR2 | P41597 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | GRK5 | P34947 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | UBE2M | P61081 | 1/20 | 0.55 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9650084 | 0.84 | HTR2A (0.71) | KDM4ESIGMAR1LMNA | |
| SCHEMBL7416122 | 0.84 | CYP3A4 (0.70) | MEN1KMT2AALDH1A1S1PR5 | |
| Hydrochloric Acid SCHEMBL9649714 | 0.83 | HTR2A (0.70) | KDM4EOPRM1OPRD1SIGMAR1LMNA | |
| SCHEMBL7415229 | 0.81 | KMT2A (0.61) | KDM4EOPRM1OPRD1MEN1KMT2A | |
| SCHEMBL4000036 | 0.80 | S1PR5 (0.58) | KDM4EMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5539621 | 0.80 | SIGMAR1 (0.65) | SIGMAR1 | |
| SCHEMBL29783820 | 0.78 | SIGMAR1 (0.67) | KDM4EGAAALDH1A1S1PR5S1PR1 | |
| SCHEMBL4958680 | 0.78 | SIGMAR1 (0.67) | KDM4EGAAALDH1A1S1PR5S1PR1 | |
| SCHEMBL7418001 | 0.78 | SLC18A3 (0.73) | KDM4E | |
| SCHEMBL11521377 | 0.78 | LMNA (0.57) | KDM4EOPRM1OPRD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198449-A | N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents | A. H. ROBINS COMPANY INCORPORATED (US) | 1993-03-30 | — | — | US | disclosed |