Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.38 |
| ▸ | F2 | P00734 | 5/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 4/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416087 | 0.93 | POLB (0.37) | TMPRSS6F2ITGB3ITGA2BITGB1 | |
| SCHEMBL7414434 | 0.91 | F2 (0.42) | TMPRSS6F2ITGB3ITGA2B | |
| SCHEMBL7414962 | 0.91 | BCL2 (0.44) | MCL1 | |
| SCHEMBL7416602 | 0.90 | ITGB3 (0.38) | TMPRSS6F2ITGB3ITGA2BITGB1 | |
| SCHEMBL7415008 | 0.90 | F2 (0.42) | TMPRSS6F2ITGB3ITGA2BITGB1 | |
| SCHEMBL7414232 | 0.89 | ITGB3 (0.37) | TMPRSS6F2ITGB3ITGA2BITGB1 | |
| SCHEMBL7412728 | 0.89 | F2 (0.39) | TMPRSS6F2ITGB3ITGA2BITGAV | |
| Trifluoroacetic Acid SCHEMBL7415404 | 0.89 | ITGB3 (0.46) | TMPRSS6F2ITGB3ITGA2BRAB9A | |
| SCHEMBL7415735 | 0.89 | F2 (0.38) | TMPRSS6F2ITGB3ITGA2BITGAV | |
| SCHEMBL7417130 | 0.89 | F2 (0.45) | TMPRSS6F2ITGB3ITGA2BF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |