Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | ADAM8 | P78325 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412629 | 0.91 | CTSL (0.43) | F2TMPRSS6ITGB3ITGA2BADAM10 | |
| SCHEMBL7419584 | 0.90 | F2 (0.42) | F2TMPRSS6ITGB3ITGA2BITGAV | |
| SCHEMBL7412728 | 0.89 | F2 (0.39) | F2TMPRSS6ITGB3ITGA2BCA12 | |
| Trifluoroacetic Acid SCHEMBL7415728 | 0.89 | ITGB3 (0.46) | F2TMPRSS6ITGB3ITGA2BCA12 | |
| SCHEMBL7417130 | 0.89 | F2 (0.45) | F2TMPRSS6ITGB3ITGA2B | |
| SCHEMBL7415413 | 0.89 | TMPRSS6 (0.38) | F2TMPRSS6ITGB3ITGA2BITGAV | |
| SCHEMBL7415235 | 0.88 | KCNA5 (0.44) | F2TMPRSS6ITGB3ITGA2BMMP2 | |
| SCHEMBL7699209 | 0.88 | F2 (0.42) | F2TMPRSS6ITGB3ITGA2BMMP2 | |
| SCHEMBL7416867 | 0.88 | NPSR1 (0.40) | F2TMPRSS6ITGB3ITGA2BMMP2 | |
| SCHEMBL7694791 | 0.88 | MMP2 (0.45) | F2TMPRSS6ITGB3ITGA2BCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |