Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409290 | 0.85 | MAPK14 (0.53) | PARP1MAPTHSD17B10KDM4EMAPK14 | |
| SCHEMBL7415475 | 0.84 | MAPT (0.49) | HTTPARP1GAAMAPTHSD17B10 | |
| SCHEMBL7412697 | 0.76 | ADORA3 (0.51) | PARP1GAAMAPTHSD17B10KDM4E | |
| SCHEMBL7416744 | 0.76 | PARP1 (0.49) | PARP1GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL7407990 | 0.76 | MAPK14 (0.53) | HTTPARP1GAAMAPTHSD17B10 | |
| SCHEMBL7415160 | 0.76 | ADORA3 (0.54) | GAAMAPTHSD17B10L3MBTL1 | |
| SCHEMBL7418663 | 0.76 | ADORA3 (0.54) | HTTPARP1GAAMAPTMAPK1 | |
| SCHEMBL7415495 | 0.74 | KDM4E (0.40) | PARP1MAPTHSD17B10KDM4EMAPK14 | |
| SCHEMBL7413449 | 0.74 | ADORA3 (0.56) | HTTGAAMAPTHSD17B10KDM4E | |
| SCHEMBL7410394 | 0.73 | ADORA3 (0.54) | MAPTKDM4EPADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026741-A1 | CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | claimed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | claimed |
| US-5908932-A | Certain pyrroloquinolinones; a new class of GABA brain receptor | NEUROGEN CORPORATION (US) | 1999-06-01 | — | — | US | disclosed |
| US-5604235-A | DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, BENZODIAZEPINE OVERDOSE; ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION (US) | 1997-02-18 | — | — | US | disclosed |
| WO-1994026741-A1 | CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |