SCHEMBL7418663

SCHEMBL7418663

O=C1c2c(c3ccccc3[nH]c2=O)C(=O)N1c1cccc(F)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.54
FAAH O00519 1/20 0.45
MGLL Q99685 1/20 0.45
MAPK14 Q16539 1/20 0.44
LMNA P02545 3/20 0.44
HPGD P15428 1/20 0.44
KDM4E B2RXH2 5/20 0.42
ALDH1A1 P00352 5/20 0.42
GAA P10253 2/20 0.42
HTT P42858 2/20 0.42
GLA P06280 1/20 0.42
HSD17B10 Q99714 3/20 0.41
METAP2 P50579 1/20 0.41
PGR P06401 1/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
TP53 P04637 1/20 0.40
PADI4 Q9UM07 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7407990 0.85 MAPK14 (0.53) ADORA3MAPK14LMNAKDM4EALDH1A1
SCHEMBL7415475 0.84 MAPT (0.49) ADORA3MAPK14LMNAHPGDKDM4E
SCHEMBL7415160 0.84 ADORA3 (0.54) ADORA3MGLLALDH1A1GAAHSD17B10
SCHEMBL7413449 0.82 ADORA3 (0.56) ADORA3MGLLLMNAHPGDKDM4E
SCHEMBL7406002 0.76 MAPK14 (0.44) MGLLMAPK14LMNAKDM4EALDH1A1
SCHEMBL7409290 0.76 MAPK14 (0.53) MAPK14LMNAHPGDKDM4EALDH1A1
SCHEMBL7412697 0.76 ADORA3 (0.51) ADORA3LMNAKDM4EALDH1A1GAA
SCHEMBL7414758 0.76 HTT (0.54) MAPK14KDM4EGAAHTTHSD17B10
SCHEMBL7415495 0.74 KDM4E (0.40) ADORA3MAPK14LMNAHPGDKDM4E
SCHEMBL7410394 0.73 ADORA3 (0.54) ADORA3LMNAHPGDKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994026741-A1 CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1994-11-24 WO claimed
US-5243049-A Gamma-aminobutyric acid antagonist NEUROGEN CORPORATION (US) 1993-09-07 US claimed
US-5908932-A Certain pyrroloquinolinones; a new class of GABA brain receptor NEUROGEN CORPORATION (US) 1999-06-01 US disclosed
US-5604235-A DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, BENZODIAZEPINE OVERDOSE; ENHANCEMENT OF MEMORY NEUROGEN CORPORATION (US) 1997-02-18 US disclosed
WO-1994026741-A1 CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1994-11-24 WO disclosed
US-5243049-A Gamma-aminobutyric acid antagonist NEUROGEN CORPORATION (US) 1993-09-07 US disclosed