Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331301 | 0.85 | REN (0.45) | RENCTSSHSD17B10CHRM1OPRL1 | |
| SCHEMBL7376719 | 0.85 | REN (0.46) | RENCTSSHSD17B10CHRM1OPRL1 | |
| SCHEMBL9556726 | 0.84 | REN (0.46) | RENHSD17B10OPRD1 | |
| SCHEMBL9556736 | 0.84 | REN (0.45) | RENHSD17B10CHRM1POLB | |
| SCHEMBL7339618 | 0.83 | REN (0.45) | RENCTSSHSD17B10CHRM1OPRL1 | |
| SCHEMBL9556569 | 0.77 | FFAR2 (0.32) | — | |
| SCHEMBL9556562 | 0.77 | REN (0.45) | RENCTSS | |
| SCHEMBL7329328 | 0.76 | REN (0.46) | RENCTSSLMNA | |
| SCHEMBL7332502 | 0.76 | KMT2A (0.41) | RENCTSSOPRL1 | |
| SCHEMBL9556441 | 0.76 | LTA4H (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | claimed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |