Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17427791 | 0.75 | MEN1 (0.42) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL7415949 | 0.73 | AR (0.40) | ARDRD2DRD4MAPTMEN1 | |
| SCHEMBL7422651 | 0.69 | AR (0.42) | ARDRD2DRD4ALDH1A1MAPT | |
| SCHEMBL4496862 | 0.69 | DRD2 (0.56) | ARDRD2DRD4ALDH1A1MAPT | |
| SCHEMBL7420307 | 0.68 | AR (0.36) | ARDRD2DRD4HRH3SMN1; SMN2 | |
| SCHEMBL8261456 | 0.68 | DRD2 (0.47) | ARDRD2DRD4ALDH1A1MAPT | |
| SCHEMBL9202117 | 0.67 | HPGD (0.36) | ARALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7417887 | 0.67 | AR (0.37) | ARDRD2DRD4ALDH1A1MAPT | |
| SCHEMBL7420370 | 0.66 | HSD17B10 (0.39) | ARDRD2DRD4ALDH1A1MAPT | |
| SCHEMBL862785 | 0.65 | ALDH1A1 (0.39) | ALDH1A1MAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |