Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 6/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417887 | 0.88 | AR (0.37) | ARSMN1; SMN2DRD2DRD4 | |
| SCHEMBL7415949 | 0.80 | AR (0.40) | ARHTR2AHTR2CSMN1; SMN2DRD2 | |
| SCHEMBL7420662 | 0.72 | MAPT (0.44) | HTR2AHTR2CSMN1; SMN2HRH3 | |
| SCHEMBL9328879 | 0.72 | CDK4 (0.52) | HTR2AHTR2C | |
| SCHEMBL108285 | 0.68 | HTR2A (0.42) | HTR2AHTR2CEGFR | |
| SCHEMBL29670034 | 0.68 | HTR2A (0.42) | HTR2AHTR2CEGFR | |
| SCHEMBL7468196 | 0.68 | AR (0.43) | ARSMN1; SMN2DRD2DRD4HRH3 | |
| SCHEMBL18307589 | 0.68 | CDK4 (0.52) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL7414805 | 0.67 | NOTUM (0.47) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL9919051 | 0.67 | AR (0.45) | ARSMN1; SMN2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |