Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261456 | 0.70 | DRD2 (0.47) | ARDRD2DRD4ATMALDH1A1 | |
| SCHEMBL7415949 | 0.69 | AR (0.40) | ARCYP3A4HTR6DRD2DRD4 | |
| SCHEMBL7468196 | 0.69 | AR (0.43) | ARDRD2DRD4ATMALDH1A1 | |
| SCHEMBL16708694 | 0.68 | MAP3K5 (0.34) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9204140 | 0.68 | GAA (0.31) | CYP3A4HTR6MAPT | |
| SCHEMBL4496862 | 0.67 | DRD2 (0.56) | ARDRD2DRD4ALDH1A1MAPT | |
| SCHEMBL22631666 | 0.65 | ADORA2A (0.50) | ARATMALDH1A1MAPTHRH3 | |
| SCHEMBL23063842 | 0.65 | ALDH1A1 (0.53) | ARDRD2DRD4ATMALDH1A1 | |
| SCHEMBL8529890 | 0.65 | DRD2 (0.46) | ARDRD2DRD4ATMALDH1A1 | |
| SCHEMBL8527546 | 0.65 | DRD2 (0.41) | ARDRD2DRD4ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |