Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30432306 | 0.68 | PKM (0.42) | GSK3BKMT2AABCC1ALDH1A1L3MBTL1 | |
| SCHEMBL2084839 | 0.68 | KMT2A (0.42) | GSK3BKMT2AABCC1ALDH1A1L3MBTL1 | |
| SCHEMBL2201666 | 0.68 | ABCC1 (0.44) | GSK3BKMT2AABCC1ALDH1A1L3MBTL1 | |
| SCHEMBL2084031 | 0.67 | GSK3B (0.39) | GSK3BKMT2AABCC1ALDH1A1L3MBTL1 | |
| SCHEMBL28587374 | 0.66 | ALDH1A1 (0.46) | KMT2AABCC1ALDH1A1L3MBTL1HPGD | |
| SCHEMBL22004182 | 0.66 | KMT2A (0.59) | KMT2AALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL2082605 | 0.66 | GSK3B (0.41) | GSK3BKMT2AABCC1ALDH1A1GAA | |
| SCHEMBL21914142 | 0.65 | KMT2A (0.58) | KMT2AALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL2198316 | 0.64 | PKM (0.40) | KMT2AOPRM1ABCC1ALDH1A1L3MBTL1 | |
| SCHEMBL3289108 | 0.63 | GSK3B (0.61) | GSK3BL3MBTL1GAAHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276035-A | Central nervous system disorders; Parkinson's disease; antidepressant and dopaminergic agent | NOVO NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0541617-A1 | 1,4-DISUBSTITUTED PIPERAZINES. | NOVO NORDISK AS (DK) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992001679-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1992-02-06 | — | — | WO | disclosed |