Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805438 | 0.73 | ALDH1A1 (0.53) | PKLRNOTUMTHRBLMNAALDH1A1 | |
| SCHEMBL2205547 | 0.73 | LMNA (0.68) | PKLRNOTUMTHRBLMNAALDH1A1 | |
| SCHEMBL2209599 | 0.73 | LMNA (0.68) | PKLRNOTUMTHRBLMNAALDH1A1 | |
| SCHEMBL12428954 | 0.73 | LMNA (0.68) | PKLRNOTUMTHRBLMNAALDH1A1 | |
| SCHEMBL8567503 | 0.71 | NOTUM (0.59) | PKLRNOTUMALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL32673424 | 0.70 | NOTUM (0.62) | PKLRNOTUMTHRBLMNAALDH1A1 | |
| SCHEMBL7416927 | 0.70 | NOTUM (0.62) | PKLRNOTUMTHRBLMNASMN1; SMN2 | |
| SCHEMBL8810927 | 0.70 | KDM4E (0.54) | LMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8570195 | 0.69 | NOTUM (0.56) | PKLRNOTUMALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6269801 | 0.69 | NOTUM (0.56) | PKLRNOTUMALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |