Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 6/20 | 0.58 |
| ▸ | MMP9 | P14780 | 4/20 | 0.58 |
| ▸ | MMP1 | P03956 | 3/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | BMP1 | P13497 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226437 | 0.89 | MMP13 (0.58) | MMP13MMP9MMP1MMP2CA1 | |
| SCHEMBL1565606 | 0.89 | MMP13 (0.58) | MMP13MMP9MMP1MMP2CA1 | |
| SCHEMBL7461414 | 0.88 | MMP13 (0.56) | MMP13MMP9MMP1MMP2CA1 | |
| SCHEMBL7417246 | 0.86 | MMP7 (0.65) | ALDH1A1MMP13MMP9MMP1MMP2 | |
| SCHEMBL13570807 | 0.86 | MMP2 (0.62) | ALDH1A1MMP13MMP9MMP1MMP2 | |
| SCHEMBL11887788 | 0.86 | MMP2 (0.62) | ALDH1A1MMP13MMP9MMP1MMP2 | |
| SCHEMBL13643222 | 0.86 | MMP2 (0.57) | ALDH1A1MMP13MMP9MMP1MMP2 | |
| SCHEMBL13570499 | 0.86 | MMP2 (0.62) | ALDH1A1MMP13MMP9MMP1MMP2 | |
| SCHEMBL13639185 | 0.86 | MMP2 (0.57) | ALDH1A1MMP13MMP9MMP1MMP2 | |
| SCHEMBL7411093 | 0.85 | MMP13 (0.60) | MMP13MMP9MMP1MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |