Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.63 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29259793 | 0.86 | ALDH1A1 (0.74) | ALDH1A1POLBSMN1; SMN2CA12CA1 | |
| SCHEMBL5960056 | 0.86 | HTT (1.00) | HTTALDH1A1POLBSMN1; SMN2SFRP1 | |
| SCHEMBL7416728 | 0.83 | HTT (0.76) | HTTALDH1A1POLBSMN1; SMN2PDE4D | |
| SCHEMBL5960103 | 0.82 | ALDH1A1 (0.79) | HTTALDH1A1POLBSMN1; SMN2SFRP1 | |
| SCHEMBL6104071 | 0.82 | HTT (0.81) | HTTALDH1A1POLBSMN1; SMN2SFRP1 | |
| SCHEMBL508554 | 0.81 | ALDH1A1 (0.77) | HTTALDH1A1POLBSMN1; SMN2PDE4D | |
| SCHEMBL9927443 | 0.80 | TPSAB1 (0.67) | ALDH1A1POLBCYP19A1TPSAB1 | |
| SCHEMBL4618123 | 0.80 | SFRP1 (0.84) | HTTALDH1A1POLBSMN1; SMN2SFRP1 | |
| SCHEMBL16863964 | 0.79 | TPSAB1 (0.59) | HTTALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL9895381 | 0.78 | TPSAB1 (0.65) | ALDH1A1POLBCYP19A1TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120148604-A1 | TRP INHIBITORS AND USES THEREOF | TRANSPOSAGEN BIOPHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120148604-A1 | TRP INHIBITORS AND USES THEREOF | TRANSPOSAGEN BIOPHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120148604-A1 | TRP INHIBITORS AND USES THEREOF | TRANSPOSAGEN BIOPHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148604-A1 | TRP INHIBITORS AND USES THEREOF | TRPC4, TRPC1, TRPC3 | HTT 1242/4885ALDH1A1 4359/4885POLB 4356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.