Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420122 | 0.75 | CACNA1H (0.37) | KDM4ECYP1A2HSD17B10PDE10AALDH1A1 | |
| SCHEMBL7379913 | 0.74 | TNKS2 (0.50) | KDM4EPDE10AALDH1A1SMN1; SMN2PARP1 | |
| SCHEMBL22118823 | 0.71 | KDM4E (0.42) | KDM4ECYP1A2HSD17B10PDE10AALDH1A1 | |
| SCHEMBL7422513 | 0.68 | ADORA3 (0.33) | KDM4E | |
| SCHEMBL22118811 | 0.68 | — | — | |
| SCHEMBL22118927 | 0.67 | ADORA3 (0.33) | KDM4EMEN1KMT2A | |
| SCHEMBL14281548 | 0.66 | PARP1 (0.46) | KDM4ECYP1A2HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL22119325 | 0.64 | CYP1A2 (0.32) | KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19236511 | 0.63 | MITF (0.47) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL7350550 | 0.62 | KMT2A (0.40) | KDM4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220856-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2002-07-10 | — | — | EP | claimed |
| WO-2001027113-A2 | PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | claimed |