Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | CDC42 | P60953 | 1/20 | 0.32 |
| ▸ | RAC1 | P63000 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555547 | 0.78 | MTNR1A (0.46) | MTNR1AMTNR1BEIF4A3L3MBTL1ALOX15 | |
| SCHEMBL7423385 | 0.75 | MTNR1A (0.43) | MTNR1AMTNR1BALOX15KDM5AKDM5B | |
| SCHEMBL5981755 | 0.69 | CASP3 (0.51) | MTNR1AMTNR1BTDP1KDM5AKDM5B | |
| SCHEMBL7420510 | 0.69 | KMT2A (0.53) | MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7469548 | 0.68 | KDM4E (0.42) | MTNR1AMTNR1BL3MBTL1ALOX15TSHR | |
| SCHEMBL4694517 | 0.68 | TDP1 (0.71) | AKR1C3AKR1C2TDP1L3MBTL1PTGS2 | |
| SCHEMBL10633957 | 0.68 | TDP1 (0.71) | AKR1C3AKR1C2TDP1L3MBTL1PTGS2 | |
| SCHEMBL7418610 | 0.67 | PPARG (0.48) | MTNR1AMTNR1BAKR1C3AKR1C2TDP1 | |
| SCHEMBL7418770 | 0.67 | MTNR1A (0.47) | MTNR1AMTNR1BALOX15VCPCYP1A2 | |
| SCHEMBL10646766 | 0.66 | KDM4E (0.47) | MTNR1AMTNR1BKDM5AKDM5BVCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |