Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385867 | 1.00 | CTSK (0.33) | CTSKCTSLCTSBCTSHSMN1; SMN2 | |
| SCHEMBL7383410 | 1.00 | CTSK (0.33) | CTSKCTSLCTSBCTSHSMN1; SMN2 | |
| SCHEMBL7381198 | 0.91 | CTSL (0.34) | CTSKCTSLCTSBCTSHKMT2A | |
| SCHEMBL7421314 | 0.91 | CTSL (0.34) | CTSKCTSLCTSBCTSHKMT2A | |
| SCHEMBL7380103 | 0.85 | MEN1 (0.32) | SMN1; SMN2KMT2AMEN1ALDH1A1MMP1 | |
| SCHEMBL7380889 | 0.85 | MEN1 (0.32) | SMN1; SMN2KMT2AMEN1ALDH1A1MMP1 | |
| SCHEMBL7410645 | 0.85 | MEN1 (0.32) | SMN1; SMN2KMT2AMEN1ALDH1A1MMP1 | |
| SCHEMBL7418375 | 0.83 | MEN1 (0.31) | SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7472659 | 0.83 | MEN1 (0.31) | SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7423731 | 0.78 | MGLL (0.39) | SMN1; SMN2KMT2AMEN1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019386-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998038179-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-09-03 | — | — | WO | disclosed |