Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14281548 | 0.70 | PARP1 (0.46) | GAAPARP1MAPTGLALMNA | |
| SCHEMBL18781842 | 0.68 | HTR2B (0.56) | PKMGAAHTR2BLMNAHRH4 | |
| SCHEMBL19236511 | 0.66 | MITF (0.47) | MAPTGLALMNA | |
| SCHEMBL7379913 | 0.66 | TNKS2 (0.50) | GAAPARP1MAPTGLA | |
| SCHEMBL22118823 | 0.63 | KDM4E (0.42) | PKMMAPTLMNA | |
| SCHEMBL22118927 | 0.62 | ADORA3 (0.33) | PKMGAA | |
| SCHEMBL7420122 | 0.62 | CACNA1H (0.37) | PKMGAAPARP1MAPTLMNA | |
| SCHEMBL5799688 | 0.61 | TNKS (0.58) | GAAPARP1MAPT | |
| SCHEMBL7422513 | 0.60 | ADORA3 (0.33) | GAA | |
| SCHEMBL17008876 | 0.59 | HTR1D (0.37) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220856-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2002-07-10 | — | — | EP | claimed |
| WO-2001027113-A2 | PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | claimed |