Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.49 |
| ▸ | F2 | P00734 | 6/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408399 | 0.96 | F2 (0.47) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| SCHEMBL7699209 | 0.92 | F2 (0.42) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| SCHEMBL7415235 | 0.92 | KCNA5 (0.44) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| SCHEMBL7412629 | 0.91 | CTSL (0.43) | ITGB3ITGA2BF2TMPRSS6CTSL | |
| SCHEMBL7694791 | 0.91 | MMP2 (0.45) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| SCHEMBL7414434 | 0.91 | F2 (0.42) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| SCHEMBL7413464 | 0.91 | F2 (0.42) | ITGB3ITGA2BF2TMPRSS6MMP2 | |
| SCHEMBL7416574 | 0.91 | ITGB3 (0.45) | ITGB3ITGA2BF2TMPRSS6CTSL | |
| SCHEMBL7415682 | 0.91 | TMPRSS6 (0.43) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7417130 | 0.91 | F2 (0.45) | ITGB3ITGA2BF2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |