Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 6/20 | 0.63 |
| ▸ | MMP13 | P45452 | 6/20 | 0.63 |
| ▸ | MMP1 | P03956 | 5/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934607 | 0.80 | MMP13 (0.78) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL6932368 | 0.77 | MMP13 (1.00) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6933323 | 0.76 | MMP13 (0.72) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL7395627 | 0.73 | MMP9 (0.76) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL8713231 | 0.72 | MMP1 (0.73) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL6928764 | 0.69 | MMP9 (0.77) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL6932190 | 0.68 | MMP9 (0.79) | MMP9MMP13MMP1 | |
| SCHEMBL6932195 | 0.67 | MMP13 (0.63) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL8843348 | 0.67 | MMP1 (0.51) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL6933879 | 0.67 | MMP1 (1.00) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054858-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042436-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-08-26 | — | — | WO | disclosed |