Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414006 | 0.83 | BACE1 (0.40) | CTSKCTSSATMBACE1CTSL | |
| SCHEMBL7419681 | 0.82 | PPARG (0.44) | CTSKPPARAPPARG | |
| SCHEMBL9538641 | 0.76 | CTSK (0.59) | CTSKCTSS | |
| SCHEMBL7104136 | 0.76 | CYP2D6 (0.58) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7417386 | 0.75 | MME (0.50) | — | |
| SCHEMBL6802106 | 0.75 | CTSK (0.68) | CTSKCTSSATMCTSLCTSB | |
| SCHEMBL27962256 | 0.74 | CTSK (0.56) | CTSKCTSSATMCTSLCTSB | |
| SCHEMBL9438871 | 0.74 | CTSK (0.57) | CTSKCTSSCTSLCTSB | |
| SCHEMBL24095930 | 0.73 | CTSK (0.50) | CTSKCTSSBACE1CTSLCTSB | |
| SCHEMBL1374859 | 0.73 | CTSK (0.63) | CTSKCTSSATMCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |