Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417898 | 0.82 | CTSK (0.47) | PPARGPPARACTSK | |
| SCHEMBL1134521 | 0.78 | PPARG (0.52) | PPARGPPARACACNA1BALDH1A1CTSK | |
| SCHEMBL7395706 | 0.76 | ALOX5 (0.45) | ALDH1A1ALOX5LPAR1LPAR5 | |
| SCHEMBL7412179 | 0.76 | ALOX5 (0.45) | ALDH1A1ALOX5LPAR1LPAR5 | |
| SCHEMBL7098744 | 0.75 | SMN1; SMN2 (0.55) | PPARGPPARAALDH1A1 | |
| SCHEMBL20415859 | 0.75 | PPARG (0.56) | PPARGPPARACACNA1BALDH1A1CTSK | |
| SCHEMBL28561280 | 0.75 | PPARG (0.56) | PPARGPPARACACNA1BALDH1A1CTSK | |
| SCHEMBL7414006 | 0.74 | BACE1 (0.40) | PPARGPPARAALDH1A1CTSK | |
| SCHEMBL20677573 | 0.74 | ALDH1A1 (0.46) | PPARGPPARACACNA1BALDH1A1AOC3 | |
| SCHEMBL16453247 | 0.74 | ALDH1A1 (0.46) | PPARGPPARACACNA1BALDH1A1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |