Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30880427 | 0.86 | KDM4E (0.50) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL27218363 | 0.86 | KDM4E (0.50) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL23350310 | 0.80 | KDM4E (0.52) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL1268537 | 0.79 | KDM4E (0.59) | KDM4EALDH1A1PARP1MEN1KMT2A | |
| SCHEMBL30804387 | 0.79 | KDM4E (0.59) | KDM4EALDH1A1PARP1MEN1KMT2A | |
| SCHEMBL14339329 | 0.79 | KDM4E (0.50) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL2943656 | 0.79 | KDM4E (0.65) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL26670852 | 0.76 | KIF11 (0.46) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL18132168 | 0.76 | AHR (0.47) | POLBKDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL20659375 | 0.75 | DAO (0.54) | POLBKDM4EALDH1A1PARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316948-A | Alpha, beta-unsaturated ketone derivative of N-methylciprofloxacin, preparation method of derivative, and application of derivative | 河南大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106279019-A | A kind of α of enrofloxacin, alpha, beta-unsaturated ketone derivant and its preparation method and application | 河南大学 | 2017-01-04 | — | — | CN | claimed |
| CN-102827187-B | Fluoroquinolone acetal isoniazone, and preparation method and application thereof | UNIV HENAN | 2014-05-14 | — | — | CN | claimed |
| CN-102827146-B | Fluoroquinolone acetal ftivazide as well as preparation method and application thereof | UNIV HENAN | 2014-01-22 | — | — | CN | claimed |
| CN-102827146-A | Fluoroquinolone acetal ftivazide as well as preparation method and application thereof | UNIV HENAN | 2012-12-19 | — | — | CN | claimed |
| CN-102827187-A | Fluoroquinolone acetal isoniazone, and preparation method and application thereof | UNIV HENAN | 2012-12-19 | — | — | CN | claimed |
| CN-106316948-A | Alpha, beta-unsaturated ketone derivative of N-methylciprofloxacin, preparation method of derivative, and application of derivative | 河南大学 | 2017-01-11 | — | — | CN | disclosed |
| CN-106279019-A | A kind of α of enrofloxacin, alpha, beta-unsaturated ketone derivant and its preparation method and application | 河南大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-104557973-B | 3,3 '-methylene of a kind of chirality piperazine quinoline ring-bis-fluoro quinolone derivatives and its preparation method and application | 河南大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-104370812-B | A kind of 3,3 '-methylene containing ring the third quinoline ring-bis-fluoro quinolone derivatives and its preparation method and application | 河南大学 | 2016-06-29 | — | — | CN | disclosed |
| CN-104557973-A | 3,3'-methene-difluoroquinolone derivative of chiral oxazine quinoline ring as well as preparation method and application of 3,3'-methene-difluoroquinolone derivative | UNIV HENAN | 2015-04-29 | — | — | CN | disclosed |
| CN-104447537-A | 3,3'-methylene-bisfluoroquinolone derivative containing ethylquinoline rings as well as preparation method and application thereof | UNIV HENAN | 2015-03-25 | — | — | CN | disclosed |
| CN-104370812-A | 3,3'-methylene-bisfluoroquinolone derivative containing cyclopropylquinoline ring as well as preparation method and application of 3,3'-methylene-bisfluoroquinolone derivative | UNIV HENAN | 2015-02-25 | — | — | CN | disclosed |
| CN-102827146-A | Fluoroquinolone acetal ftivazide as well as preparation method and application thereof | UNIV HENAN | 2012-12-19 | — | — | CN | disclosed |
| CN-102827187-A | Fluoroquinolone acetal isoniazone, and preparation method and application thereof | UNIV HENAN | 2012-12-19 | — | — | CN | disclosed |
| CN-102459169-A | Redox drug derivatives | BRADFORD PHARMA LTD | 2012-05-16 | — | — | CN | disclosed |
| US-20120077974-A1 | REDOX DRUG DERIVATIVES | REDX PHARMA PLC (GB) | 2012-03-29 | — | — | US | disclosed |
| EP-2429991-A1 | REDOX DRUG DERIVATIVES | Redx Pharma Limited (GB) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131054-A9 | REDOX DRUG DERIVATIVES | BRADFORD PHARMA LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |
| WO-2010131054-A1 | REDOX DRUG DERIVATIVES | BRADFORD PHARMA LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077974-A1 | REDOX DRUG DERIVATIVES | NOX4, AOX1, ALDH5A1 | POLB 2160/4885KDM4E 1523/4885ALDH1A1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.