Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.51 |
| ▸ | HPGDS | O60760 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741851 | 1.00 | PARP1 (0.51) | PARP1HPGDSHCRTR1HCRTR2PDE4B | |
| SCHEMBL30689172 | 0.91 | PARP1 (0.45) | PARP1HCRTR1HCRTR2PDE4BADORA2A | |
| SCHEMBL743449 | 0.88 | PTGS1 (0.57) | PARP1HPGDSHCRTR1HCRTR2PTGS1 | |
| SCHEMBL743450 | 0.88 | PTGS1 (0.57) | PARP1HPGDSHCRTR1HCRTR2PTGS1 | |
| SCHEMBL20029041 | 0.87 | PARP1 (0.52) | PARP1HPGDSHCRTR1HCRTR2PTGS1 | |
| SCHEMBL762497 | 0.87 | PARP1 (0.52) | PARP1HPGDSHCRTR1HCRTR2PTGS1 | |
| SCHEMBL19951502 | 0.85 | PARP1 (0.70) | PARP1 | |
| SCHEMBL739188 | 0.83 | HPGDS (0.57) | PARP1HPGDSPOLBPRMT5 | |
| SCHEMBL19408169 | 0.83 | HPGDS (0.57) | PARP1HPGDSPOLBPRMT5 | |
| SCHEMBL762565 | 0.83 | HPGDS (0.57) | PARP1HPGDSPOLBPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |