Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 12/20 | 0.53 |
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743449 | 1.00 | PTGS1 (0.57) | PTGS1PTGS2PARP1HPGDSHCRTR1 | |
| SCHEMBL762497 | 0.89 | PARP1 (0.52) | PTGS1PTGS2PARP1HPGDSHCRTR1 | |
| SCHEMBL20029041 | 0.89 | PARP1 (0.52) | PTGS1PTGS2PARP1HPGDSHCRTR1 | |
| SCHEMBL741851 | 0.88 | PARP1 (0.51) | PTGS1PTGS2PARP1HPGDSHCRTR1 | |
| SCHEMBL741850 | 0.88 | PARP1 (0.51) | PTGS1PTGS2PARP1HPGDSHCRTR1 | |
| SCHEMBL19951502 | 0.87 | PARP1 (0.70) | PARP1 | |
| SCHEMBL739188 | 0.84 | HPGDS (0.57) | PARP1HPGDSKDM4EPRMT5 | |
| SCHEMBL762565 | 0.84 | HPGDS (0.57) | PARP1HPGDSKDM4EPRMT5 | |
| SCHEMBL19408169 | 0.84 | HPGDS (0.57) | PARP1HPGDSKDM4EPRMT5 | |
| SCHEMBL30689172 | 0.78 | PARP1 (0.45) | PARP1HCRTR1HCRTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |