Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427469 | 0.92 | AGTR1 (0.40) | ALOX5APAGTR1AGTR2AKR1A1AKR1B1 | |
| SCHEMBL7420996 | 0.91 | LMNA (0.40) | ALOX5APOXER1PPARGKMT2ALMNA | |
| SCHEMBL7425988 | 0.90 | AGTR1 (0.36) | ALOX5APAGTR1AGTR2OXER1PLA2G2A | |
| SCHEMBL7420228 | 0.89 | MAPT (0.38) | PPARGKMT2ASMN1; SMN2 | |
| SCHEMBL7472730 | 0.89 | MEN1 (0.39) | ALOX5APKMT2ASMN1; SMN2 | |
| SCHEMBL7420923 | 0.89 | AKR1B1 (0.40) | AGTR1AGTR2AKR1A1AKR1B1PPARG | |
| SCHEMBL687131 | 0.88 | ALOX5AP (0.47) | ALOX5APPLA2G2APPARGDPP4KMT2A | |
| SCHEMBL29611861 | 0.88 | ALOX5AP (0.47) | ALOX5APPLA2G2APPARGDPP4KMT2A | |
| SCHEMBL7418596 | 0.87 | MAPT (0.38) | ALOX5APPLA2G2APPARGDPP4 | |
| SCHEMBL7424199 | 0.86 | PLA2G2A (0.34) | ALOX5APAGTR1AGTR2AKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |