Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416794 | 0.88 | LOXL2 (0.42) | KMT2ACOMTDPP4PSIP1LOXL2 | |
| SCHEMBL4793133 | 0.85 | KMT2A (0.39) | KMT2ACOMTDPP4LOXL2GAA | |
| SCHEMBL7416470 | 0.84 | KMT2A (0.42) | KMT2ADPP4LOXL2P2RX7CCR9 | |
| SCHEMBL18283289 | 0.82 | COMT (0.41) | KMT2ACOMTPSIP1GAAP2RX7 | |
| SCHEMBL17372075 | 0.81 | DPP4 (0.41) | KMT2ADPP4LOXL2KDM4EMAPT | |
| SCHEMBL7533479 | 0.80 | DPP4 (0.36) | KMT2ADPP4LOXL2CCR9MAOA | |
| SCHEMBL21061787 | 0.78 | KMT2A (0.56) | KMT2ACOMTPSIP1GAAP2RX7 | |
| SCHEMBL7423716 | 0.76 | DPP4 (0.37) | KMT2ADPP4LOXL2CCR9NFE2L2 | |
| SCHEMBL10834405 | 0.76 | COMT (0.51) | KMT2ACOMTPSIP1GAAKDM4E | |
| SCHEMBL7417140 | 0.75 | FEN1 (0.43) | KMT2ACOMTDPP4LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | claimed |