Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.80 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418883 | 0.90 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7416090 | 0.88 | TAS2R14 (0.74) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7418172 | 0.81 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7420943 | 0.81 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7206100 | 0.80 | L3MBTL1 (0.76) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7421609 | 0.79 | PDE4D (0.63) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7413611 | 0.79 | TAS2R14 (0.68) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL11877545 | 0.79 | CA9 (0.69) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL7422229 | 0.78 | TAS2R14 (0.89) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7424700 | 0.76 | PDE4D (0.66) | PDE4APDE4BPDE4CPDE4DTAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |