Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.53 |
| ▸ | CTSL | P07711 | 7/20 | 0.53 |
| ▸ | CTSB | P07858 | 7/20 | 0.53 |
| ▸ | CTSK | P43235 | 7/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023323 | 0.88 | CTSS (0.42) | CTSSCTSLCTSBCTSK | |
| SCHEMBL6565010 | 0.78 | CTSS (0.34) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7021490 | 0.76 | CTSK (0.56) | CTSSCTSLCTSBCTSK | |
| SCHEMBL6184079 | 0.75 | CTSS (0.67) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL7021496 | 0.75 | CTSS (0.41) | CTSSCTSLCTSBCTSK | |
| SCHEMBL25198329 | 0.74 | CTSS (0.50) | CTSSCTSLCTSBCTSKTLR2 | |
| SCHEMBL25198330 | 0.74 | CTSS (0.50) | CTSSCTSLCTSBCTSKTLR2 | |
| SCHEMBL6183576 | 0.74 | CTSS (0.65) | CTSSCTSLCTSBCTSKPREP | |
| SCHEMBL9900827 | 0.73 | CTSL (0.63) | CTSSCTSLCTSBCTSKPREP | |
| SCHEMBL6567042 | 0.72 | CTSS (0.35) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |