Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514442 | 0.86 | IDO1 (0.44) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL28905847 | 0.86 | BRD9 (0.44) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL2737224 | 0.85 | NLRP3 (0.56) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL1771858 | 0.84 | IDO1 (0.47) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL17230179 | 0.82 | IDO1 (0.44) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL30850148 | 0.81 | IDO1 (0.42) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL24166675 | 0.81 | IDO1 (0.43) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL8837511 | 0.81 | CXCL8 (0.49) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL8214432 | 0.81 | IDO1 (0.43) | IDO1NLRP3TP53MAPTLMNA | |
| SCHEMBL1951665 | 0.81 | CXCL8 (0.49) | IDO1NLRP3TP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349570-A1 | RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE | THE UPJOHN COMPANY (US) | 1990-01-10 | — | — | EP | disclosed |
| WO-1988007053-A1 | RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE | THE UPJOHN COMPANY (US) | 1988-09-22 | — | — | WO | disclosed |