Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951582 | 0.91 | CXCL8 (0.49) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL8837511 | 0.91 | CXCL8 (0.49) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL1951665 | 0.91 | CXCL8 (0.49) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL2737224 | 0.86 | NLRP3 (0.56) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL1771858 | 0.85 | IDO1 (0.47) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL17230179 | 0.84 | IDO1 (0.44) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL24166675 | 0.82 | IDO1 (0.43) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL28360191 | 0.82 | LMNA (0.48) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL7419310 | 0.81 | IDO1 (0.45) | IDO1NLRP3LMNAPOLBTP53 | |
| SCHEMBL2880191 | 0.81 | LMNA (0.54) | LMNAPOLBRXFP1BRD9METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |