Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.44 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.44 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.44 |
| ▸ | ME2 | P23368 | 3/20 | 0.44 |
| ▸ | ME1 | P48163 | 3/20 | 0.44 |
| ▸ | ME3 | Q16798 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443913 | 0.82 | TPSAB1 (0.61) | NAMPTF2PRSS1TPSAB1TPSD1 | |
| SCHEMBL7424872 | 0.81 | TPSAB1 (0.53) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7422920 | 0.80 | TPSAB1 (0.74) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7579428 | 0.78 | TPSAB1 (0.41) | NAMPTGAAPOLBSMN1; SMN2F2 | |
| SCHEMBL7495608 | 0.78 | TPSAB1 (0.57) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL4099538 | 0.77 | KMT2A (0.57) | POLBSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL7444750 | 0.76 | ALDH1A1 (0.47) | GAAPOLBSMN1; SMN2F2PRSS1 | |
| Hydrochloric Acid SCHEMBL7319435 | 0.76 | KMT2A (0.56) | POLBSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL10680103 | 0.75 | SMN1; SMN2 (0.42) | GAAPOLBSMN1; SMN2F2PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7436446 | 0.75 | TPSAB1 (0.47) | F2PRSS1TPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1073103-C | Compounds and compositions for treating diseases associated with tryptase activity | ARRIS PHARM CORP (US) | 2001-10-17 | — | — | CN | disclosed |
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| CN-1226892-A | Novel compounds and compositions for the treatment of diseases associated with tryptase activity | ARRIS PHARM CORP (US) | 1999-08-25 | — | — | CN | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |