Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | APAF1 | O14727 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419083 | 0.82 | NR1H2 (0.39) | HSD17B3HDAC8NAMPTGAAALDH1A1 | |
| SCHEMBL7898985 | 0.65 | RNASEH1 (0.50) | NOTUMRNASEH1MEN1KMT2AGAA | |
| SCHEMBL677618 | 0.65 | BRD4 (0.50) | NOTUMRNASEH1HPGD | |
| SCHEMBL8966163 | 0.65 | ACHE (0.46) | NOTUMRNASEH1HSD17B3NPC1RAB9A | |
| SCHEMBL38662990 | 0.65 | KDM4E (0.54) | NOTUMRAB9AALOX15MEN1KMT2A | |
| SCHEMBL12226485 | 0.64 | NOTUM (0.55) | NOTUMHSD17B3NPC1RAB9AHDAC8 | |
| SCHEMBL8610167 | 0.64 | ALDH1A1 (0.65) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL7335861 | 0.64 | NOTUM (0.42) | NOTUMRNASEH1HSD17B3NPC1RAB9A | |
| SCHEMBL19410673 | 0.64 | NOTUM (0.58) | NOTUMMAPTHPGD | |
| Acetone SCHEMBL27589367 | 0.63 | CYP1A2 (0.52) | NOTUMHSD17B3NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602145-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0702671-A4 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1996-06-19 | — | — | EP | disclosed |
| EP-0702671-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994029273-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-22 | — | — | WO | disclosed |