Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CBX7 | O95931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7962173 | 0.99 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BDRD2DRD3 | |
| SCHEMBL7962662 | 0.93 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7954106 | 0.92 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7967410 | 0.92 | DRD2 (0.35) | AVPR2AVPR1AAVPR1BDRD2DRD3 | |
| SCHEMBL7966199 | 0.91 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMAP3K7ADRA1D | |
| Hydrochloric Acid SCHEMBL7954290 | 0.91 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMAP3K7ADRA1D | |
| SCHEMBL7972286 | 0.88 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BMAP3K7ABCB1 | |
| Hydrochloric Acid SCHEMBL7967237 | 0.87 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BMAP3K7ADRA1D | |
| Hydrochloric Acid SCHEMBL7427358 | 0.87 | ADRA1D (0.32) | AVPR2AVPR1AAVPR1BDRD2DRD3 | |
| SCHEMBL7479643 | 0.86 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BMAP3K7CBX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |